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Omics score: 0

Multi-Omics Analyses Revealed Conserved Aging Signatures in Mice

ABSTRACT: Studies on aging have largely included one or two OMICS layers, which may not necessarily reflect the signatures of other layers. Moreover, most aging studies have often compared very young (4-5 wks) mice with old (24 months) mice which does not reflect the aging transition after the attainment of adulthood. Therefore, we aimed to study and compared muti-OMICS aging signatures across key metabolic tissues of mature adults (6 months) and old (24 months) C57BL/6J mice (the most commonly used mouse strain). Here we compared the differentially regulated genes and enriched pathways for transcriptome, proteome and epigenome (H3K27ac, H3K4me3, H3K27me3, DNA methylation) across liver, heart, and quadriceps muscle. The major aging associated pathways cross multiple layers and tissues are decreased RNA metabolism, transcription, and translation at transcript and protein levels however increased potential of transcription at DNA methylation and H3K27ac levels.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Quadriceps, Heart, Liver, Gastrocnemius

SUBMITTER: Evan Williams

LAB HEAD: Ruedi Aebersold

PROVIDER: PXD011142 | Pride | 2021-11-30

REPOSITORIES: Pride

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			Action	DRS
	E1608021307_feature_alignment_requant.tsv.gz	Tabular
	E1608021307_matrix.xlsx	Xlsx
	MultiTissueLibrary_LiverSkeletalMuscleHeartBATWholeBrain.TraML	Other
	YWU_BXD_E1508071446.pep.xml	Pepxml
	YWU_BXD_E1508071446.prot.xml	Xml

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