Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell, Blood Plasma, Peripheral Blood Mononuclear Cell, Blood
SUBMITTER: Leon Bichmann
LAB HEAD: Professor Oliver Kohlbacher
PROVIDER: PXD011628 | Pride | 2019-10-14
REPOSITORIES: Pride
Items per page: 1 - 5 of 120 |
Nature communications 20161121
Although mutations may represent attractive targets for immunotherapy, direct identification of mutated peptide ligands isolated from human leucocyte antigens (HLA) on the surface of native tumour tissue has so far not been successful. Using advanced mass spectrometry (MS) analysis, we survey the melanoma-associated immunopeptidome to a depth of 95,500 patient-presented peptides. We thereby discover a large spectrum of attractive target antigen candidates including cancer testis antigens and pho ...[more]