Proteomics

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Activin A and NK cell function

ABSTRACT: Natural killer (NK) cells are innate lymphocytes that play a major role in immunosurveillance against tumor initiation and metastasis spread. Signals and checkpoints that regulate NK cell fitness and function in the tumor microenvironment are not well defined. Transforming grow factor (TGF)- is a recognized suppressor of NK cells that inhibits IL-15 dependent signaling events and induces cellular transdifferentiation, however the role of other SMAD signaling pathways in NK cells is unknown. We used a global, label-free proteomics approach to compare the protein expression profiles of NK cells in the presence of TGF-b or activin-A.

INSTRUMENT(S): impact II

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Natural Killer Cell

SUBMITTER: Laura Dagley  

LAB HEAD: Fernando Souza-Fonseca-Guimaraes

PROVIDER: PXD011672 | Pride | 2020-04-06

REPOSITORIES: Pride

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P3643_RIITGFb_1_1_1_1_01_10633.d.zip Other
P3643_RIITGFb_1_2_1_1_01_10634.d.zip Other
P3643_RIITGFb_1_3_1_1_01_10635.d.zip Other
P3643_RIITGFb_1_4_1_1_01_10636.d.zip Other
P3643_RIIUS_1_1_1_1_01_10613.d.zip Other
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Natural killer (NK) cells are innate lymphocytes that play a major role in immunosurveillance against tumor initiation and metastatic spread. The signals and checkpoints that regulate NK cell fitness and function in the tumor microenvironment are not well defined. Transforming growth factor-β (TGF-β) is a suppressor of NK cells that inhibits interleukin-15 (IL-15)-dependent signaling events and increases the abundance of receptors that promote tissue residency. Here, we showed that NK cells expr  ...[more]

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