Proteomics

Dataset Information

0

Tc1 and Tc2 secretion proteome evaluation


ABSTRACT: The goal of this project is to dissect the mechanism by which Tc1 and Tc2 effector subtypes effect cell physiology in vitro. I utilized cellular proteomics to determine Tc1 and Tc2 secretion patterns and identify inflammatory factors that regulate cell polarization and physiology in vitro.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart, T Cell, Fibroblast

SUBMITTER: Elizabeth Flynn  

LAB HEAD: Elizabeth Flynn

PROVIDER: PXD011757 | Pride | 2022-02-15

REPOSITORIES: Pride

Dataset's files

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Publications

Chronic <i>Porphyromonas gingivalis</i> lipopolysaccharide induces adverse myocardial infarction wound healing through activation of CD8<sup>+</sup> T cells.

Zaidi Yusra Y   Corker Alexa A   Vasileva Valeriia Y VY   Oviedo Kimberly K   Graham Connor C   Wilson Kyrie K   Martino John J   Troncoso Miguel M   Broughton Philip P   Ilatovskaya Daria V DV   Lindsey Merry L ML   DeLeon-Pennell Kristine Y KY  

American journal of physiology. Heart and circulatory physiology 20211001 5


Oral and gum health have long been associated with incidence and outcomes of cardiovascular disease. Periodontal disease increases myocardial infarction (MI) mortality by sevenfold through mechanisms that are not fully understood. The goal of this study was to evaluate whether lipopolysaccharide (LPS) from a periodontal pathogen accelerates inflammation after MI through memory T-cell activation. We compared four groups [no MI, chronic LPS, <i>day 1</i> after MI, and <i>day 1</i> after MI with ch  ...[more]

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