Dataset Information
Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Glomerular Visceral Epithelial Cell, Cell Culture
SUBMITTER: 
Tong Liu
LAB HEAD: Evren U. Azeloglu
PROVIDER: PXD011761 | Pride | 2019-03-29
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Evren_Ctrl1.mzid.gz | Mzid | |||
| Evren_Ctrl1.mzid_Evren_Ctrl1.MGF | Mzid | |||
| Evren_Ctrl1.mzid_Evren_Ctrl1.pride.mgf.gz | Mzid | |||
| Evren_Ctrl1.pride.mztab.gz | Mztab | |||
| Evren_Ctrl1_low.raw | Raw |
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Publications
Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity.
Nature communications 20190503 1
Nephrotoxicity is a critical adverse event that leads to discontinuation of kinase inhibitor (KI) treatment. Here we show, through meta-analyses of FDA Adverse Event Reporting System, that dasatinib is associated with high risk for glomerular toxicity that is uncoupled from hypertension, suggesting a direct link between dasatinib and podocytes. We further investigate the cellular effects of dasatinib and other comparable KIs with varying risks of nephrotoxicity. Dasatinib treated podocytes show ...[more]
