Dataset Information

MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis

ABSTRACT: microRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis

OTHER RELATED OMICS DATASETS IN: GSE99686

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Huvec Cell

SUBMITTER: Craig Lawless

LAB HEAD: Stefanie Nicoli

PROVIDER: PXD011882 | Pride | 2019-02-19

REPOSITORIES: Pride

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MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis.

Moro Albertomaria A Driscoll Tristan P TP Boraas Liana C LC Armero William W Kasper Dionna M DM Baeyens Nicolas N Jouy Charlene C Mallikarjun Venkatesh V Swift Joe J Ahn Sang Joon SJ Lee Donghoon D Zhang Jing J Gu Mengting M Gerstein Mark M Schwartz Martin M Nicoli Stefania S

Nature cell biology 20190211 3

Vertebrate tissues exhibit mechanical homeostasis, showing stable stiffness and tension over time and recovery after changes in mechanical stress. However, the regulatory pathways that mediate these effects are unknown. A comprehensive identification of Argonaute 2-associated microRNAs and mRNAs in endothelial cells identified a network of 122 microRNA families that target 73 mRNAs encoding cytoskeletal, contractile, adhesive and extracellular matrix (CAM) proteins. The level of these microRNAs ...[more]

PMID: 30742093

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