Dataset Information

GSK3 alpha/beta knockout Mouse Podocytes proteomics

ABSTRACT: This is a set of proteomics performed on murine podocytes derived from a GSK3alpha/beta floxed mouse. GSK3 has been knocked down in the podocytes using lentiviral cre. This was performed 3 days prior to the analysis. For more details see paper entitled "Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function" published in Nature Communications.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Glomerular Visceral Epithelial Cell

DISEASE(S): Kidney Disease

SUBMITTER: Richard Coward

LAB HEAD: Professor Richard Coward

PROVIDER: PXD012145 | Pride | 2019-11-14

REPOSITORIES: pride

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Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function.

Hurcombe J A JA Hartley P P Lay A C AC Ni L L Bedford J J JJ Leader J P JP Singh S S Murphy A A Scudamore C L CL Marquez E E Barrington A F AF Pinto V V Marchetti M M Wong L-F LF Uney J J Saleem M A MA Mathieson P W PW Patel S S Walker R J RJ Woodgett J R JR Quaggin S E SE Welsh G I GI Coward R J M RJM

Nature communications 20190124 1

Albuminuria affects millions of people, and is an independent risk factor for kidney failure, cardiovascular morbidity and death. The key cell that prevents albuminuria is the terminally differentiated glomerular podocyte. Here we report the evolutionary importance of the enzyme Glycogen Synthase Kinase 3 (GSK3) for maintaining podocyte function in mice and the equivalent nephrocyte cell in Drosophila. Developmental deletion of both GSK3 isoforms (α and β) in murine podocytes causes late neonata ...[more]

PMID: 30679422

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Dataset Information

GSK3 alpha/beta knockout Mouse Podocytes proteomics

Dataset's files

Publications

Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function.

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