Coxsackievirus B persistence modifies the secretome of pancreatic ductal cells in a virus-strain-specific manner, part 2
Ontology highlight
ABSTRACT: The group B Coxsackieviruses can establish persistent infections in human cells, and these infections have been linked to chronic diseases including type 1 diabetes. Still, only little is known about persistent Coxsackievirus B infection induced changes in human pancreas. We have established persistent Coxsackievirus B1 infections in human pancreatic duct cell line using two different virus strains, and studied infection-induced changes in protein secretion using mass spectrometry-based proteomics. Persistent Coxsackievirus B1 infections caused broad changes in protein secretion, for example changes regulated secretory pathway. Strikingly, many changes differed between the virus strains, including extensive shut down of antiviral immune responses by one of the viruses. Our results provide novel information about persistent Coxsackievirus B infection induced changes in human pancreas and about the potential heterogeneity in the outcomes of the infections.
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Niina Lietzen
LAB HEAD: Riitta Lahesmaa
PROVIDER: PXD012154 | Pride | 2019-08-06
REPOSITORIES: Pride
ACCESS DATA