Proteomics

Dataset Information

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Proteome and phosphoproteome dynamics of CVB3 infected cells

ABSTRACT: Viruses are obligate intracellular parasites that reshape the ultrastructure, composition and metabolism of host cells to suit their specific needs, although disparate viruses may modify their host in different ways. Such changes may be specifically induced by the virus to support the infection or be part of cellular antiviral responses or stress responses. Here, using state-of-the-art quantitative (phospho)proteomics, we reveal the unique proteome and phosphoproteome dynamics that occur in the host cells infected with the enterovirus coxsackievirus B3 (CVB3).

INSTRUMENT(S): Orbitrap Fusion, Q Exactive

ORGANISM(S): Homo Sapiens (human) Coxsackievirus B3

TISSUE(S): Cell Culture

SUBMITTER: Piero Giansanti  

LAB HEAD: Albert J. R. Heck

PROVIDER: PXD011163 | Pride | 2020-07-23

REPOSITORIES: Pride

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L1_A5_20170309_HP_virus_project_phoshpo_30pr_0M_A_2.raw Raw
L1_A5_20170309_HP_virus_project_phoshpo_30pr_0M_A_3.raw Raw
L1_A5_20170309_HP_virus_project_phoshpo_30pr_0M_B.raw Raw
L1_A5_20170309_HP_virus_project_phoshpo_30pr_0M_B_2.raw Raw
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Publications

The group of enteroviruses contains many important pathogens for humans, including poliovirus, coxsackievirus, rhinovirus, as well as newly emerging global health threats such as EV-A71 and EV-D68. Here, we describe an unbiased, system-wide and time-resolved analysis of the proteome and phosphoproteome of human cells infected with coxsackievirus B3. Of the ~3,200 proteins quantified throughout the time course, a large amount (~25%) shows a significant change, with the majority being downregulate  ...[more]

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