Proteomics

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786-O LC-MS/MS - Loss of BAP1 Results in Growth Inhibition and Enhances Mesenchymal-Epithelial Transition in Kidney Tumor Cells

ABSTRACT: BRCA1-associated protein 1 (BAP1) is a member of the ubiquitin C‑terminal hydrolase family of deubiquitinating enzymes and is implicated in transcriptional regulation. The BAP1 gene is mutated in about 10% of patients with clear cell renal cell carcinoma (ccRCC), the most common form of renal cancer, suggesting that BAP1 may be a tumor suppressor. However, whether BAP1 influences the progression of ccRCC tumors expressing WT BAP1 is unclear. Here, we assessed the expression and function of BAP1 using human ccRCC specimens and cell lines.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Kidney

DISEASE(S): Renal Clear Cell Carcinoma

SUBMITTER: Pengsheng Chen  

LAB HEAD: Haiteng Deng

PROVIDER: PXD012288 | Pride | 2019-04-18

REPOSITORIES: Pride

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Loss of BAP1 Results in Growth Inhibition and Enhances Mesenchymal-Epithelial Transition in Kidney Tumor Cells.

Chen Pengsheng P   Wang Huan H   Zhang Wenhao W   Chen Yuling Y   Lv Yang Y   Wu Di D   Guo Mingzhou M   Deng Haiteng H  

Molecular & cellular proteomics : MCP 20190416 7

BRCA1-associated protein 1 (BAP1) is a member of the ubiquitin C-terminal hydrolase family of deubiquitinating enzymes and is implicated in transcriptional regulation. The <i>BAP1</i> gene is mutated in about 10% of patients with ccRCC, the most common form of renal cancer, suggesting that BAP1 is a tumor suppressor. However, whether <i>BAP1</i> influences the progression of ccRCC tumors expressing wild-type (WT) <i>BAP1</i> is unclear. Here, we assessed the expression and function of BAP1 using  ...[more]

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