Dataset Information

In-vitro and in-vivo effects of an environmental PPARγ metabolic disruptor, triphenyl phosphate, on adipogenic differentiation and metabolic functions

ABSTRACT: Comparison of TPhP and Rosi exposure to adipocytes.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture

SUBMITTER: Benjamin Blum

LAB HEAD: Andrew Emili

PROVIDER: PXD012337 | Pride | 2021-09-08

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20180919_RH_SKim_Proteome-2e5.raw	Raw
	20180919_RH_SKim_Proteome-5e4.raw	Raw
	20180924_RH_SK_Phospho.raw	Raw
	20181010-RH_SK_Prot_15ul.raw	Raw
	20181012_RH_SK__Prot_ReducedGradient.raw	Raw

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Publications

Triphenyl phosphate is a selective PPARγ modulator that does not induce brite adipogenesis in vitro and in vivo.

Kim Stephanie S Rabhi Nabil N Blum Benjamin C BC Hekman Ryan R Wynne Kieran K Emili Andrew A Farmer Stephen S Schlezinger Jennifer J JJ

Archives of toxicology 20200718 9

Triphenyl phosphate (TPhP) is an environmental PPARγ ligand, and growing evidence suggests that it is a metabolic disruptor. We have shown previously that the structurally similar ligand, tributyltin, does not induce brite adipocyte gene expression. Here, using in vivo and in vitro models, we tested the hypothesis that TPhP is a selective PPARγ ligand, which fails to induce brite adipogenesis. C57BL/6 J male mice were fed either a low or very high-fat diet for 13 weeks. From weeks 7-13, mice wer ...[more]

PMID: 32683515

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