Proteomics

Dataset Information

0

Integrated analysis of label-free quantitative proteomics and bioinformatics reveal insights into signaling pathways in male breast cancer

ABSTRACT: The project contains raw and result files from a proteomic profiling of a male breast cancer (MBC) case. Label-free quantification-mass spectrometry (LFQ-MS) and bioinformatics analysis were employed to investigate the differentially expressed proteins (DEPs) among distinct tissue samples: the primary breast tumor, axillary metastatic lymph nodes and the adjacent non-tumor breast tissue. An additional proteomic comparative analysis was performed with a primary breast tumor of a female patient. A number of Ingenuity® Pathway Analysis (IPA) (QIAGEN Inc.) and functional annotation tools were used to further analyze the DEPs. Altogether, our findings revealed deregulated proteins into signaling pathways involved in the cancer development and provided a landscape of proteomic data for the MBC research.

INSTRUMENT(S): LTQ Orbitrap XL ETD

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Breast, Lymph Node, Breast Cancer Cell

DISEASE(S): Breast Cancer

SUBMITTER: Michel Batista  

LAB HEAD: Enilze Maria de Souza Fonseca Ribeiro

PROVIDER: PXD012453 | Pride | 2021-09-08

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
FLN_1.RAW Raw
FLN_2.RAW Raw
FLN_3.RAW Raw
FNT_1.RAW Raw
FNT_2.RAW Raw
Items per page:
1 - 5 of 21
altmetric image

Publications

Male breast cancer (MBC) is a rare malignancy that accounts for about 1.8% of all breast cancer cases. In contrast to the high number of the "omics" studies in breast cancer in women, only recently molecular approaches have been performed in MBC research. High-throughput proteomics based methodologies are promisor strategies to characterize the MBC proteomic signatures and their association with clinico-pathological parameters. In this study, the label-free quantification-mass spectrometry and b  ...[more]

Similar Datasets

Proteomics High-throughput mass spectrometry and bioinformatics analysis of breast cancer proteomic data
2019-07-15 | PXD012431 | Pride
Methylation profiling Epigenome analysis of primary breast cancer tumors and different types of recurrences.
2013-12-24 | GSE44870 | GEO
Transcriptomics Gene expression profiling of CD4+ T cells infiltrating human breast cancer (Discovery Set)
2013-06-17 | E-GEOD-36765 | biostudies-arrayexpress
Genomics miRNAs expression in breast cancer tumor tissues with or without axillary lymph nodes metastastsis
2019-06-30 | GSE100453 | GEO
Transcriptomics Epigenome analysis of primary breast cancer tumors and different types of recurrences.
2013-12-24 | E-GEOD-44870 | biostudies-arrayexpress
Transcriptomics Gene expression profiling of CD4+ T cells infiltrating human breast cancer (Discovery Set)
2013-06-17 | GSE36765 | GEO
Transcriptomics To identify novel metastasis-associated gene candidates in colorectal cancer
2010-10-16 | E-GEOD-24639 | biostudies-arrayexpress
Transcriptomics Pubching spatial transcriptomics of MDA-MB-231 xenografts
2022-04-22 | GSE184720 | GEO
Transcriptomics Integrative Transcriptomic and Proteomic Analysis Reveals Mechanisms of Silica-induced Pulmonary Fibrosis in Rats
2022-01-12 | GSE188520 | GEO
Transcriptomics Effect of human breast tumor supernatant on normal CD4+ T cells (Preliminary Experiment)
2013-06-17 | E-GEOD-36768 | biostudies-arrayexpress