Pubching spatial transcriptomics of MDA-MB-231 xenografts
Ontology highlight
ABSTRACT: Gene expressional analysis with single cell scale by next generation sequencer revealed clonal dissemination in cancer metastasis. To reveal expressional heterogeneity and cell-cell interaction in the primary tumor and the metastasis, we performed transcriptome analysis of micro-tissues dissected from triple negative breast cancer (TNBC) cell line MDA-MB-231 xenograft model by our automated tissue micro-dissection punching technology. This “multiple micro-tissue transcriptome analysis” revealed that there existed three clusters in primary tumor and axillary lymph-node metastasis, two of which were cancer stem cell-like clusters (CD44/MYC-high, HMGA1-high).
ORGANISM(S): Homo sapiens
PROVIDER: GSE184720 | GEO | 2022/04/22
REPOSITORIES: GEO
ACCESS DATA