Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Wouter Kallemeijn
LAB HEAD: Edward W. Tate
PROVIDER: PXD012722 | Pride | 2019-11-14
REPOSITORIES: Pride
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MaxQuantOutput.tar.gz | Other | |||
WWK20180601-Experimentalsetup.xlsx | Xlsx | |||
wwk20180517_h1-f1.index | Other | |||
wwk20180517_h1-f1.raw | Raw | |||
wwk20180517_h1-f2.index | Other |
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Cell chemical biology 20190418 6
On-target, cell-active chemical probes are of fundamental importance in chemical and cell biology, whereas poorly characterized probes often lead to invalid conclusions. Human N-myristoyltransferase (NMT) has attracted increasing interest as target in cancer and infectious diseases. Here we report an in-depth comparison of five compounds widely applied as human NMT inhibitors, using a combination of quantitative whole-proteome N-myristoylation profiling, biochemical enzyme assays, cytotoxicity, ...[more]