Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Breast Epithelium
DISEASE(S): Breast Cancer
SUBMITTER: Florian Finkernagel
LAB HEAD: Till Adhikary
PROVIDER: PXD012818 | Pride | 2019-08-06
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
GPM00500047071.mgf | Mgf | |||
GPM00500047071.mzid.gz | Mzid | |||
GPM00500047071.mzid_GPM00500047071.MGF | Mzid | |||
GPM00500047071.mzid_GPM00500047071.pride.mgf.gz | Mzid | |||
GPM00500047071.pride.mgf.gz | Mgf |
Items per page: 5 1 - 5 of 42 |
Legrand Nathalie N Bretscher Clemens L CL Zielke Svenja S Wilke Bernhard B Daude Michael M Fritz Barbara B Diederich Wibke E WE Adhikary Till T
Nucleic acids research 20191001 18
In the absence of ligands, the nuclear receptor PPARβ/δ recruits the NCOR and SMRT corepressors, which form complexes with HDAC3, to canonical target genes. Agonistic ligands cause dissociation of corepressors and enable enhanced transcription. Vice versa, synthetic inverse agonists augment corepressor recruitment and repression. Both basal repression of the target gene ANGPTL4 and reinforced repression elicited by inverse agonists are partially insensitive to HDAC inhibition. This raises the qu ...[more]