Proteomics

Dataset Information

0

PPARbeta/delta chip-masspectrometry


ABSTRACT: MDA-MB231-luc2 cells were treated with either L165,041 or PT-S264 and ChIP-MS was performed according to the RIME-protocol (Active Motif Inc.).

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Breast Epithelium

DISEASE(S): Breast Cancer

SUBMITTER: Florian Finkernagel  

LAB HEAD: Till Adhikary

PROVIDER: PXD012818 | Pride | 2019-08-06

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
GPM00500047071.mgf Mgf
GPM00500047071.mzid.gz Mzid
GPM00500047071.mzid_GPM00500047071.MGF Mzid
GPM00500047071.mzid_GPM00500047071.pride.mgf.gz Mzid
GPM00500047071.pride.mgf.gz Mgf
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Publications

PPARβ/δ recruits NCOR and regulates transcription reinitiation of ANGPTL4.

Legrand Nathalie N   Bretscher Clemens L CL   Zielke Svenja S   Wilke Bernhard B   Daude Michael M   Fritz Barbara B   Diederich Wibke E WE   Adhikary Till T  

Nucleic acids research 20191001 18


In the absence of ligands, the nuclear receptor PPARβ/δ recruits the NCOR and SMRT corepressors, which form complexes with HDAC3, to canonical target genes. Agonistic ligands cause dissociation of corepressors and enable enhanced transcription. Vice versa, synthetic inverse agonists augment corepressor recruitment and repression. Both basal repression of the target gene ANGPTL4 and reinforced repression elicited by inverse agonists are partially insensitive to HDAC inhibition. This raises the qu  ...[more]

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