Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Xenopus Laevis (african Clawed Frog)
TISSUE(S): Sperm
SUBMITTER: jerome jullien
LAB HEAD: jerome jullien
PROVIDER: PXD012853 | Pride | 2020-05-29
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 11 |
Oikawa Mami M Simeone Angela A Hormanseder Eva E Teperek Marta M Gaggioli Vincent V O'Doherty Alan A Falk Emma E Sporniak Matthieu M D'Santos Clive C Franklin Valar Nila Roamio VNR Kishore Kamal K Bradshaw Charles R CR Keane Declan D Freour Thomas T David Laurent L Grzybowski Adrian T AT Ruthenburg Alexander J AJ Gurdon John J Jullien Jerome J
Nature communications 20200713 1
Sperm contributes genetic and epigenetic information to the embryo to efficiently support development. However, the mechanism underlying such developmental competence remains elusive. Here, we investigated whether all sperm cells have a common epigenetic configuration that primes transcriptional program for embryonic development. Using calibrated ChIP-seq, we show that remodelling of histones during spermiogenesis results in the retention of methylated histone H3 at the same genomic location in ...[more]