Proteomics

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Mass spectrometry-based characterization of the virion proteome and phosphoproteome of human cytomegalovirus

ABSTRACT: The assembly of human cytomegalovirus (HCMV) virions is an orchestrated process that requires, as an essential prerequisite, the complex crosstalk between viral structural proteins. So far, however, the mechanisms governing the successive steps in the constitution of virion protein complexes remained elusive. Protein phosphorylation is a key regulator determining the sequential changes in conformation, binding, dynamics and stability of proteins in the course of multiprotein assembly. Here, we present new results to complete knowledge on HCMV virion proteome and phosphoproteome. Thus, a novel dataset of viral and cellular proteins contained in HCMV virions has been generated, providing a basis for future analyses of individual phosphorylation steps and sites involved in the orchestrated assembly of HCMV virion-specific multiprotein complexes.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human) Human Cytomegalovirus (strain Ad169) (hhv-5) (human Herpesvirus 5)

SUBMITTER: Yohann Couté  

LAB HEAD: Virginie Brun

PROVIDER: PXD012921 | Pride | 2020-06-05

REPOSITORIES: Pride

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Dataset's files

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Action DRS
HCMV virion phosphoproteome.pride.mztab.gz Mztab
HCMV virion proteome.pride.mztab.gz Mztab
HCMVvirionphosphoproteome.mzid.gz Mzid
HCMVvirionproteome.mzid.gz Mzid
QEx2_019011.mgf Mgf
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Publications

Mass Spectrometry-Based Characterization of the Virion Proteome, Phosphoproteome, and Associated Kinase Activity of Human Cytomegalovirus.

Couté Yohann Y   Kraut Alexandra A   Zimmermann Christine C   Büscher Nicole N   Hesse Anne-Marie AM   Bruley Christophe C   De Andrea Marco M   Wangen Christina C   Hahn Friedrich F   Marschall Manfred M   Plachter Bodo B  

Microorganisms 20200530 6

The assembly of human cytomegalovirus (HCMV) virions is an orchestrated process that requires, as an essential prerequisite, the complex crosstalk between viral structural proteins. Currently, however, the mechanisms governing the successive steps in the constitution of virion protein complexes remain elusive. Protein phosphorylation is a key regulator determining the sequential changes in the conformation, binding, dynamics, and stability of proteins in the course of multiprotein assembly. In t  ...[more]

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