Dataset Information

Label-free proteomics reveal that plasma protein expression differs between colorectal cancer patients according to tumor stage, location, patient survival, preoperative radiotherapy status, or gender.

ABSTRACT: Colorectal cancer (CRC) is the third most common cancer worldwide and is a heterogeneous disease, with differences between cancer in the right colon, left colon, and rectum. In this study, plasma samples from CRC patients with varying stage (II or III), primary tumor location (right colon, left colon, or rectum) and survival (survived or died due to CRC) were studied with quantitative label-free proteomics using ultra-definition MSE. Patients were also divided into subgroups based on preoperative radiotherapy status and gender. Further analysis subsequently identified multiple plasma proteins whose expression differed depending on tumor stage, location, patient survival, preoperative radiotherapy status, or gender.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Colon Cancer

SUBMITTER: Sakari Joenväärä

LAB HEAD: Risto Renkonen

PROVIDER: PXD013150 | Pride | 2019-08-22

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20181011_CAJ_CRC_SERUM_01.raw.zip	Raw
	20181011_CAJ_CRC_SERUM_02.raw.zip	Raw
	20181011_CAJ_CRC_SERUM_03.raw.zip	Raw
	20181011_CAJ_CRC_SERUM_04.raw.zip	Raw
	20181011_CAJ_CRC_SERUM_05.raw.zip	Raw

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Publications

Preoperative Radiotherapy Leads to Significant Differences in the Plasma Protein Profile of Rectal Cancer Patients.

Holm Matilda M Joenväärä Sakari S Saraswat Mayank M Tohmola Tiialotta T Ristimäki Ari A Renkonen Risto R Haglund Caj C

Oncology 20200415 7

<h4>Introduction</h4>Colorectal cancer (CRC) is the third most common cancer worldwide, accounting for 10% of the global cancer burden. Rectal cancer accounts for around 30% of CRC cases, and patients with resectable rectal cancer are often given preoperative radiotherapy (PRT) to reduce the rate of local recurrence. The human plasma proteome is an exceptionally complex proteome and ideal to study due to its ability to reflect the presence of diseases such as cancer and the ease of obtaining blo ...[more]

PMID: 32294655

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