Proteomics

Dataset Information

0

Quantitative phosphoproteome analyses of human macrophage-like THP-1 cells following infection with virulent Mycobacterium tuberculosis and avirulent M. bovis BCG, respectively.


ABSTRACT: In this project we conducted a comprehensive analysis of expression and global phosphorylation status of the host proteins following infection with virulent and avirulent mycobacteria. Our objective is to identify previously uncharacterized proteins of host macrophages that are specifically expressed and phosphorylated in response to Mtb and BCG, respectively and may play important role in regulating their intracellular survival

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Macrophage

DISEASE(S): Pulmonary Tuberculosis

SUBMITTER: Renu Goel  

LAB HEAD: Dr. Nisheeth Agarwal

PROVIDER: PXD013171 | Pride | 2020-05-15

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
tc_s293p_F10_z05556.raw Raw
tc_s293p_F11_z05557.raw Raw
tc_s293p_F12_z05558.raw Raw
tc_s293p_F1_z05547.raw Raw
tc_s293p_F2_z05548.raw Raw
Items per page:
1 - 5 of 14
altmetric image

Publications

Relative and Quantitative Phosphoproteome Analysis of Macrophages in Response to Infection by Virulent and Avirulent <i>Mycobacteria</i> Reveals a Distinct Role of the Cytosolic RNA Sensor RIG-I in <i>Mycobacterium tuberculosis</i> Pathogenesis.

Choudhary Eira E   Bullen C Korin CK   Goel Renu R   Singh Alok Kumar AK   Praharaj Monali M   Thakur Preeti P   Dhiman Rohan R   Bishai William R WR   Agarwal Nisheeth N  

Journal of proteome research 20200514 6


Comparative phosphoproteomics of <i>Mycobacterium tuberculosis</i> (Mtb)- and <i>Mycobacterium bovis</i> BCG (BCG)-infected macrophages could be instrumental in understanding the characteristic post-translational modifications of host proteins and their subsequent involvement in determining Mtb pathogenesis. To identify proteins acquiring a distinct phosphorylation status, herein, we compared the phosphorylation profile of macrophages upon exposure to Mtb and BCG. We observed a significant depho  ...[more]

Similar Datasets

2024-10-08 | PXD051187 | Pride
2021-01-28 | E-MTAB-9449 | biostudies-arrayexpress
2011-12-30 | E-GEOD-32249 | biostudies-arrayexpress
2014-09-01 | E-GEOD-58810 | biostudies-arrayexpress
2022-01-26 | E-MTAB-11345 | biostudies-arrayexpress
2022-01-14 | E-MTAB-11107 | biostudies-arrayexpress
2015-09-10 | E-GEOD-45386 | biostudies-arrayexpress
2019-05-15 | PXD006141 | Pride
2010-07-29 | E-GEOD-21149 | biostudies-arrayexpress
2018-03-23 | PXD006473 | Pride