Proteomics

Dataset Information

0

Proteomics analysis of the Enterobacter cloacae response to imipenem

ABSTRACT: Recently, we have reported on a highly drug-resistant carbapenemase-producing isolate of Enterobacter cloacae (Nepal et al., Virulence. 2018; 9: 1377-1389). In the present study, we asked the question whether and, if so, how this isolate responds to a sub-inhibitory challenge with the antibiotic imipenem. To answer this question, we applied a SILAC proteomics approach that allowed the quantification of changes in the relative abundance of bacterial protein in response to imipenem. The results show that the investigated E. cloacae isolate mounts a highly specific response to counteract the detrimental effects of imipenem.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Enterobacter Cloacae

SUBMITTER: Sandra Maass  

LAB HEAD: Dörte Becher

PROVIDER: PXD013412 | Pride | 2021-08-10

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
180926_O1_P2_MA_Suru_A1_02_180926135437.raw Raw
180926_O1_P2_MA_Suru_A1_03.raw Raw
180926_O1_P2_MA_Suru_A1_04.raw Raw
180926_O1_P2_MA_Suru_A1_05.raw Raw
180926_O1_P2_MA_Suru_A1_06.raw Raw
Items per page:
1 - 5 of 102
altmetric image

Publications

Proteomic Charting of Imipenem Adaptive Responses in a Highly Carbapenem Resistant Clinical <i>Enterobacter roggenkampii</i> Isolate.

Nepal Suruchi S   Maaß Sandra S   Grasso Stefano S   Cavallo Francis M FM   Bartel Jürgen J   Becher Dörte D   Bathoorn Erik E   van Dijl Jan Maarten JM  

Antibiotics (Basel, Switzerland) 20210428 5

Gram-negative bacteria belonging to the <i>Enterobacter cloacae</i> complex are increasingly implicated in difficult-to-treat nosocomial infections, as exemplified by a recently characterized highly carbapenem-resistant clinical <i>Enterobacter roggenkampii</i> isolate with sequence type (ST) 232. While mechanisms of carbapenem resistance are well-understood, little is known about the responses of highly drug-resistant bacteria to these antibiotics. Our present study was therefore aimed at chart  ...[more]

Similar Datasets

Proteomics Yeast glutamine tRNA synthetase doxycycline shut-off
2020-02-12 | PXD017140 | Pride
Proteomics Toward the quantitative characterization of arginine phosphorylations in Staphylococcus aureus
2018-10-29 | PXD009874 | Pride
Transcriptomics Transcription profiling of Pseudomonas aeruginosa of the sulfate starvation response
2008-06-16 | E-GEOD-8408 | biostudies-arrayexpress
Proteomics Staphylococcus aureus isolates from the gut and the blood are ‘separated’ by host barrier integrity
2023-03-11 | PXD030971 | Pride
Proteomics Cell-based characterization of caspase-3 cleavage sites by LATE and HYATNE
2023-06-27 | PXD036648 | Pride
Transcriptomics Relationship between tolerance and persistence mechanisms in Acinetobacter baumannii strains with AbkAB Toxin-Antitoxin system
2018-02-09 | GSE110207 | GEO
Proteomics The identification of bacterial protein interaction partners pointed out to new intracellular functions of Francisella tularensis glyceraldehyde-3-phosphate dehydrogenase
2020-08-31 | PXD019739 | Pride
Proteomics Another layer of complexity in Staphylococcus aureus methionine biosynthesis control: Unusual RNase III-driven T-box riboswitch cleavage determines met operon mRNA stability and decay
2021-02-18 | PXD022677 | Pride
Transcriptomics The impact of heat stress on imipenem susceptibility in imipenem resistant NTHi
2019-01-15 | E-MTAB-6237 | biostudies-arrayexpress
Proteomics The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression
2023-08-11 | PXD040948 | Pride