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Exosomes proteome of human lung cancer cell lines 95C and 95D

ABSTRACT: Exosomes in the microenvironment play key roles in cellular signal transduction. The biological function of exosomes in cancer metastasis and progression, however, is still unknown.We used quantitative proteomics in this study to decipher the proteome of cellular exosomes derived from highly/lowly metastatic lung cancer cells and bioinformatics analysis showed that the differential proteins were associated with metastasis.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Lung Cancer

SUBMITTER: Zhi Qiao

LAB HEAD: Hua Xiao

PROVIDER: PXD013419 | Pride | 2019-06-17

REPOSITORIES: Pride

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			Action	DRS
	C3_QZ_20171107-01.raw	Raw
	C3_QZ_20171107-02.raw	Raw
	C3_QZ_20171107-03.raw	Raw
	D3_QZ_20171107-01.raw	Raw
	D3_QZ_20171107-02.raw	Raw

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Publications

Cancer Cell Derived Small Extracellular Vesicles Contribute to Recipient Cell Metastasis Through Promoting HGF/c-Met Pathway.

Qiao Zhi Z Zhang Yan Y Ge Maolin M Liu Sha S Jiang Xiaoteng X Shang Zhi Z Liu Han H Cao Chengxi C Xiao Hua H

Molecular & cellular proteomics : MCP 20190613 8

Cancer progression is frequently caused by metastasis and leads to significantly increased mortality. Cell derived extracellular vesicles, including exosomes, in the microenvironment play key roles in cellular signal transduction, whereas their biological function in cancer metastasis and progression needs in-depth investigation. Here, we initially demonstrate that the small extracellular vesicles (sEVs) derived from highly metastatic lung cancer cells exhibited great capacity to promote the pro ...[more]

PMID: 31196968

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MicroRNA profile of cells and exosomes

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