Proteomics

Dataset Information

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The long noncoding RNA neuroLNC modulates neurotransmitter release interacting with a neurodegeneration-associated protein


ABSTRACT: The roles of long noncoding RNAs (lncRNAs) in synaptic transmission and neuronal development are emerging. Here we applied an integrated bioinformatic/biological screening strategy to identify lncRNAs that regulate synaptic vesicle release. We identified neuroLNC, a conserved neuron-specific nuclear lncRNA that modulates synaptic vesicle release, presynaptic calcium influx, neurite elongation and neuronal migration. In neurons neuroLNC interacts with a neurodegeneration-associated protein and tunes a set of presynaptic transcripts implicated in neurotransmitter release.

OTHER RELATED OMICS DATASETS IN: GSE131103

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

SUBMITTER: Sunit Mandad  

LAB HEAD: Eugenio F. Fornasiero

PROVIDER: PXD013434 | Pride | 2020-05-26

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
08_Supplementary_Table.xlsx Xlsx
S_Mandad_Sarva_040317_L1_R1_1.raw Raw
S_Mandad_Sarva_040317_L1_R1_2.raw Raw
S_Mandad_Sarva_040317_L1_R1_3.raw Raw
S_Mandad_Sarva_040317_L1_R1_4.raw Raw
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Publications

The long noncoding RNA <i>neuroLNC</i> regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43.

Keihani S S   Kluever V V   Mandad S S   Bansal V V   Rahman R R   Fritsch E E   Gomes L Caldi LC   Gärtner A A   Kügler S S   Urlaub H H   Wren J D JD   Bonn S S   Rizzoli S O SO   Fornasiero E F EF  

Science advances 20191218 12


The cellular and the molecular mechanisms by which long noncoding RNAs (lncRNAs) may regulate presynaptic function and neuronal activity are largely unexplored. Here, we established an integrated screening strategy to discover lncRNAs implicated in neurotransmitter and synaptic vesicle release. With this approach, we identified <i>neuroLNC</i>, a neuron-specific nuclear lncRNA conserved from rodents to humans. <i>NeuroLNC</i> is tuned by synaptic activity and influences several other essential a  ...[more]

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