Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: GSE131103
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Brain
SUBMITTER: Sunit Mandad
LAB HEAD: Eugenio F. Fornasiero
PROVIDER: PXD013434 | Pride | 2020-05-26
REPOSITORIES: pride
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08_Supplementary_Table.xlsx | Xlsx | |||
S_Mandad_Sarva_040317_L1_R1_1.raw | Raw | |||
S_Mandad_Sarva_040317_L1_R1_2.raw | Raw | |||
S_Mandad_Sarva_040317_L1_R1_3.raw | Raw | |||
S_Mandad_Sarva_040317_L1_R1_4.raw | Raw |
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Keihani S S Kluever V V Mandad S S Bansal V V Rahman R R Fritsch E E Gomes L Caldi LC Gärtner A A Kügler S S Urlaub H H Wren J D JD Bonn S S Rizzoli S O SO Fornasiero E F EF
Science advances 20191218 12
The cellular and the molecular mechanisms by which long noncoding RNAs (lncRNAs) may regulate presynaptic function and neuronal activity are largely unexplored. Here, we established an integrated screening strategy to discover lncRNAs implicated in neurotransmitter and synaptic vesicle release. With this approach, we identified <i>neuroLNC</i>, a neuron-specific nuclear lncRNA conserved from rodents to humans. <i>NeuroLNC</i> is tuned by synaptic activity and influences several other essential a ...[more]