Proteomics

Dataset Information

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Cerebrospinal fluid 20 μg protein digest mixed-mode fractionation 11 fractions


ABSTRACT: A CSF fractionation experiment was conducted, where trypsin digested 20 µg un-depleted CSF peptides were separated into eleven fractions and analysed using an QExactive HF, resulting in 1194 identified proteins.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebrospinal Fluid

SUBMITTER: Astrid Guldbrandsen  

LAB HEAD: Frode S. Berven

PROVIDER: PXD013449 | Pride | 2020-09-25

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
151119_20ug_MM10.mgf Mgf
151119_20ug_MM10.pride.mgf.gz Mgf
151119_20ug_MM10.raw Raw
151119_20ug_MM11.mgf Mgf
151119_20ug_MM11.pride.mgf.gz Mgf
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Publications

Development of robust targeted proteomics assays for cerebrospinal fluid biomarkers in multiple sclerosis.

Guldbrandsen Astrid A   Lereim Ragnhild Reehorst RR   Jacobsen Mari M   Garberg Hilde H   Kroksveen Ann Cathrine AC   Barsnes Harald H   Berven Frode S FS  

Clinical proteomics 20200918


<h4>Background</h4>Verification of cerebrospinal fluid (CSF) biomarkers for multiple sclerosis and other neurological diseases is a major challenge due to a large number of candidates, limited sample material availability, disease and biological heterogeneity, and the lack of standardized assays. Furthermore, verification studies are often based on a low number of proteins from a single discovery experiment in medium-sized cohorts, where antibodies and surrogate peptides may differ, thus only pr  ...[more]

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