Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Retinal Pigment Epithelial Cell
SUBMITTER: Stefan Hoening
LAB HEAD: Stefan Höning
PROVIDER: PXD013468 | Pride | 2019-11-12
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 8 |
Wrobel Antoni G AG Kadlecova Zuzana Z Kamenicky Jan J Yang Ji-Chun JC Herrmann Torsten T Kelly Bernard T BT McCoy Airlie J AJ Evans Philip R PR Martin Stephen S Müller Stefan S Salomon Susanne S Sroubek Filip F Neuhaus David D Höning Stefan S Owen David J DJ
Developmental cell 20190801 4
Clathrin-mediated endocytosis (CME) is key to maintaining the transmembrane protein composition of cells' limiting membranes. During mammalian CME, a reversible phosphorylation event occurs on Thr156 of the μ2 subunit of the main endocytic clathrin adaptor, AP2. We show that this phosphorylation event starts during clathrin-coated pit (CCP) initiation and increases throughout CCP lifetime. μ2Thr156 phosphorylation favors a new, cargo-bound conformation of AP2 and simultaneously creates a binding ...[more]