Dataset Information

LC-MSMS analysis of API5-FGF2 interactome

ABSTRACT: We determined the crystal structure of the complex, and identified critical residues driving the protein interaction.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: BYUNG IL LEE

LAB HEAD: Byung Il Lee

PROVIDER: PXD013517 | Pride | 2020-04-23

REPOSITORIES: pride

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Publications

Regulation of mRNA export through API5 and nuclear FGF2 interaction.

Bong Seoung Min SM Bae Seung-Hyun SH Song Bomin B Gwak HyeRan H Yang Seung-Won SW Kim Sunshin S Nam Seungyoon S Rajalingam Krishnaraj K Oh Se Jin SJ Kim Tae Woo TW Park SangYoun S Jang Hyonchol H Lee Byung Il BI

Nucleic acids research 20200601 11

API5 (APoptosis Inhibitor 5) and nuclear FGF2 (Fibroblast Growth Factor 2) are upregulated in various human cancers and are correlated with poor prognosis. Although their physical interaction has been identified, the function related to the resulting complex is unknown. Here, we determined the crystal structure of the API5-FGF2 complex and identified critical residues driving the protein interaction. These findings provided a structural basis for the nuclear localization of the FGF2 isoform lack ...[more]

PMID: 32383752

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			Action	DRS
	LBI_API5_4M.raw	Raw
	LBI_API5_Mock.raw	Raw
	LBI_API5_Mock_vs_WT_vs_4M.mgf	Mgf
	LBI_API5_Mock_vs_WT_vs_4M.msf	Msf
	LBI_API5_Mock_vs_WT_vs_4M.mzML	Mzml