Proteomics

Dataset Information

0

Effect of depletion of clpP2, clpX and clpC1 genes on whole cell proteome profile of Mycobacterium tuberculosis H37Rv


ABSTRACT: Global protein alteration in Mycobacterium tuberculosis H37 RV ( Mtb-H37RV) having depletion of Clpx ,Clp2 and ClpC1 were accessed using 4 plex iTRAQ label.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Mycobacterium Tuberculosis Mycobacterium Tuberculosis H37rv

SUBMITTER: Nisheeth Agarwal  

LAB HEAD: Nisheeth Agarwal

PROVIDER: PXD013589 | Pride | 2020-05-14

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
CLPSET1.1.wiff Wiff
CLPSET1.1.wiff.scan Wiff
CLPSET1.2.wiff Wiff
CLPSET1.2.wiff.scan Wiff
CLPSET1.3.wiff Wiff
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Publications

The unfoldase ClpC1 of <i>Mycobacterium tuberculosis</i> regulates the expression of a distinct subset of proteins having intrinsically disordered termini.

Lunge Ajitesh A   Gupta Radhika R   Choudhary Eira E   Agarwal Nisheeth N  

The Journal of biological chemistry 20200514 28


The human pathogen <i>Mycobacterium tuberculosis</i> (Mtb) harbors a well-orchestrated Clp (caseinolytic protease) proteolytic machinery consisting of two oligomeric segments, a barrel-shaped heterotetradecameric protease core comprising the ClpP1 and ClpP2 subunits, and hexameric ring-like ATP-dependent unfoldases composed of ClpX or ClpC1. The roles of the ClpP1P2 protease subunits are well-established in Mtb, but the potential roles of the associated unfoldases, such as ClpC1, remain elusive.  ...[more]

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