Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Cell Culture, Cardiac Muscle Cell
SUBMITTER: Andreas Tholey
LAB HEAD: Prof. Andreas Tholey
PROVIDER: PXD013718 | Pride | 2019-06-24
REPOSITORIES: Pride
Action | DRS | |||
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150517_AH_A10A17substrates_mix_A10.raw | Raw | |||
150517_AH_A10A17substrates_mix_A17.raw | Raw | |||
150517_AH_A10A17substrates_mix_control.raw | Raw | |||
260419_AH_C_A10.raw | Raw | |||
260419_AH_C_A17.raw | Raw |
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Cellular and molecular life sciences : CMLS 20190617 2
Disintegrin and metalloproteinases (ADAMs) 10 and 17 can release the extracellular part of a variety of membrane-bound proteins via ectodomain shedding important for many biological functions. So far, substrate identification focused exclusively on membrane-anchored ADAM10 and ADAM17. However, besides known shedding of ADAM10, we identified ADAM8 as a protease capable of releasing the ADAM17 ectodomain. Therefore, we investigated whether the soluble ectodomains of ADAM10/17 (sADAM10/17) exhibit ...[more]