Proteomics

Dataset Information

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Tissue Proteome Profiling of Ovarian cancer in Pakistani Population.


ABSTRACT: Ovarian cancer is the 5th main cause of death from cancer in females, worldwide. An early and accurate diagnosis of ovarian carcinoma is likely to improve clinical outcome of patients in terms of reduced morbidity and mortality. The objective of our project is the proteome profiling of ovarian malignant and non-malignant tissue samples to find potential biomarkers of disease diagnosis and prognosis. In this project, we have used a systematic protein profiling approach involving 2-dimensional gel electrophoresis coupled with MALDI-TOF MS analysis for identification of biomarkers of ovarian cancer. The associated research paper is in preparation.

INSTRUMENT(S): ultraflex

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Ovary, Left Ovary, Right Ovary

DISEASE(S): Malignant Neoplasm Of Ovary

SUBMITTER: Muhammad Akhtar  

LAB HEAD: Muhammad Akhtar, School of Biological Sciences, University of the Punjab, Lahore, Pakistan

PROVIDER: PXD013827 | Pride | 2019-11-27

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
ANXA2.fasta Fasta
ANXA4.fasta Fasta
ANXA5.fasta Fasta
ANXA6.fasta Fasta
B1516.dat Other
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Publications

Upregulated Expression of Calcium-Dependent Annexin A6: A Potential Biomarker of Ovarian Carcinoma.

Noreen Shahzadi S   Gardner Qurratulann Afza QA   Fatima Iram I   Sadaf Saima S   Akhtar Muhammad Waheed MW  

Proteomics. Clinical applications 20200109 2


<h4>Purpose</h4>An early and accurate diagnosis of ovarian carcinoma (OC) may reduce morbidity and mortality of the patients. To improve the clinical outcome in OC patients, the present study is aimed at identifying robust biomarkers for early OC diagnosis. EXPERIMENTAL DESIGN: In order to look for early-stage protein markers, a systematic protein profiling approach involving 2-dimensional electrophoresis coupled with mass spectrometric analyses of human malignant and non-malignant ovarian biops  ...[more]

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