Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ, LTQ Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Heart, Smooth Muscle Cell
DISEASE(S): Cardiovascular System Disease
SUBMITTER: Phillip Wilmarth
LAB HEAD: Nabil J. Alkayed
PROVIDER: PXD013952 | Pride | 2022-04-13
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 18 |
Alkayed Nabil J NJ Cao Zhiping Z Qian Zu Yuan ZY Nagarajan Shanthi S Liu Xuehong X Nelson Jonathan W JW Xie Fuchun F Li Bingbing B Fan Wei W Liu Lijuan L Grafe Marjorie R MR Davis Catherine M CM Xiao Xiangshu X Barnes Anthony P AP Kaul Sanjiv S
American journal of physiology. Cell physiology 20220406 5
Arachidonic acid metabolites epoxyeicosatrienoates (EETs) and hydroxyeicosatetraenoates (HETEs) are important regulators of myocardial blood flow and coronary vascular resistance (CVR), but their mechanisms of action are not fully understood. We applied a chemoproteomics strategy using a clickable photoaffinity probe to identify G protein-coupled receptor 39 (GPR39) as a microvascular smooth muscle cell (mVSMC) receptor selective for two endogenous eicosanoids, 15-HETE and 14,15-EET, which act o ...[more]