Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap, LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain, Liver, Kidney
DISEASE(S): Disease Free
SUBMITTER: Kenneth Lum
LAB HEAD: Alan Saghatelian
PROVIDER: PXD017539 | Pride | 2020-03-09
REPOSITORIES: pride
Action | DRS | |||
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061917_ADTRPKO_KIDNEY_B_1.RAW | Raw | |||
061917_ADTRPKO_KIDNEY_B_2.RAW | Raw | |||
061917_ADTRPKO_KIDNEY_B_3.RAW | Raw | |||
061917_ADTRPKO_KIDNEY_B_4.RAW | Raw | |||
061917_ADTRPKO_KIDNEY_B_5.RAW | Raw |
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The Journal of biological chemistry 20200309 18
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a newly discovered class of signaling lipids with anti-inflammatory and anti-diabetic properties. However, the endogenous regulation of FAHFAs remains a pressing but unanswered question. Here, using MS-based FAHFA hydrolysis assays, LC-MS-based lipidomics analyses, and activity-based protein profiling, we found that androgen-induced gene 1 (AIG1) and androgen-dependent TFPI-regulating protein (ADTRP), two threonine hydrolases, control FAHFA l ...[more]