Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: GSE131650
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Andreas-David Brunner
LAB HEAD: Matthias Mann
PROVIDER: PXD014031 | Pride | 2020-03-06
REPOSITORIES: Pride
Action | DRS | |||
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FullProteome_sORF.rar | Other | |||
HLA.rar | Other | |||
Pulldowns.rar | Other | |||
txt_FullProteome_sORF.rar | Other | |||
txt_HLA_sORF.rar | Other |
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Science (New York, N.Y.) 20200301 6482
Ribosome profiling has revealed pervasive but largely uncharacterized translation outside of canonical coding sequences (CDSs). In this work, we exploit a systematic CRISPR-based screening strategy to identify hundreds of noncanonical CDSs that are essential for cellular growth and whose disruption elicits specific, robust transcriptomic and phenotypic changes in human cells. Functional characterization of the encoded microproteins reveals distinct cellular localizations, specific protein bindin ...[more]