Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain, Oligodendrocyte Precursor Cell, Cell Culture
DISEASE(S): Schizophrenia
SUBMITTER: Bradley Smith
LAB HEAD: Daniel Martins-de-Souza
PROVIDER: PXD014188 | Pride | 2022-10-13
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
2018_10_review_human.fasta | Fasta | |||
CN_Mito_MalK.csv | Csv | |||
CN_Mito_MalK_Peps.csv | Csv | |||
CN_Mito_SuccK.csv | Csv | |||
CN_Mito_SuccK_Peps.csv | Csv |
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Smith Bradley Joseph BJ Brandão-Teles Caroline C Zuccoli Giuliana S GS Reis-de-Oliveira Guilherme G Fioramonte Mariana M Saia-Cereda Verônica M VM Martins-de-Souza Daniel D
Journal of personalized medicine 20220830 9
Two protein post-translational modifications, lysine succinylation and malonylation, are implicated in protein regulation, glycolysis, and energy metabolism. The precursors of these modifications, succinyl-CoA and malonyl-CoA, are key players in central metabolic processes. Both modification profiles have been proven to be responsive to metabolic stimuli, such as hypoxia. As mitochondrial dysfunction and metabolic dysregulation are implicated in schizophrenia and other psychiatric illnesses, the ...[more]