Proteomics

Dataset Information

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Investigating the Succinylome and Malonylome of Schizophrenia


ABSTRACT: The succinylome and malonylome of human oligodendrocyte precursors (MO3.13 line) and postmortem brain tissue (whole lysates and mitochondrial enrichments) were studied with shotgun mass spectrometry. The goal was to determine what changes in oligodendrocytes are induced with the addition of the NMDA receptor antagonist MK-801 and compare this with schizophrenia brain tissue; to visualize the changes that antipsychotics have on the succinylome and malonylome and how this may relate to their side effects; to see what changes induced by MK-801 are returned to more control-like levels and how this may relate to mechanisms of drug action; and to see what changes in these PTMs may exist in vivo in patients with schizophrenia compared to healthy controls.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain, Oligodendrocyte Precursor Cell, Cell Culture

DISEASE(S): Schizophrenia

SUBMITTER: Bradley Smith  

LAB HEAD: Daniel Martins-de-Souza

PROVIDER: PXD014188 | Pride | 2022-10-13

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
2018_10_review_human.fasta Fasta
CN_Mito_MalK.csv Csv
CN_Mito_MalK_Peps.csv Csv
CN_Mito_SuccK.csv Csv
CN_Mito_SuccK_Peps.csv Csv
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Publications

Protein Succinylation and Malonylation as Potential Biomarkers in Schizophrenia.

Smith Bradley Joseph BJ   Brandão-Teles Caroline C   Zuccoli Giuliana S GS   Reis-de-Oliveira Guilherme G   Fioramonte Mariana M   Saia-Cereda Verônica M VM   Martins-de-Souza Daniel D  

Journal of personalized medicine 20220830 9


Two protein post-translational modifications, lysine succinylation and malonylation, are implicated in protein regulation, glycolysis, and energy metabolism. The precursors of these modifications, succinyl-CoA and malonyl-CoA, are key players in central metabolic processes. Both modification profiles have been proven to be responsive to metabolic stimuli, such as hypoxia. As mitochondrial dysfunction and metabolic dysregulation are implicated in schizophrenia and other psychiatric illnesses, the  ...[more]

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