Dataset Information

Idiopathic epiretinal membrane compared with inner limiting membrane

ABSTRACT: We compared the proteome of epiretinal membrane of iERM with the proteome of the inner limiting membrane (ILM) of idiopathic macular hole (iMH). Twelve epiretinal membrane samples from iERM were compared with twelve ILM samples obtained from from iMH. Proteomic analysis was conducted with LFQ nLC-MS/MS. Discovery data were searched against the Uniprot Homo sapiens protein database using MaxQuant.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Retina

SUBMITTER: Bent Honoré

LAB HEAD: Bent Honoré

PROVIDER: PXD014286 | Pride | 2019-07-18

REPOSITORIES: Pride

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Source:

			Action	DRS
	081016_10_Christos_E21_UM_1h_50cm_2mcrol.raw	Raw
	081016_11_Christos_E22_UM_1h_50cm_2mcrol.raw	Raw
	081016_12_Christos_E23_UM_1h_50cm_2mcrol.raw	Raw
	081016_13_Christos_M1_UM_1h_50cm_2mcrol.raw	Raw
	081016_14_Christos_M2_UM_1h_50cm_2mcrol.raw	Raw

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Proteomics reveals a set of highly enriched proteins in epiretinal membrane compared with inner limiting membrane.

Christakopoulos Christos C Cehofski Lasse Jørgensen LJ Christensen Steen Rugaard SR Vorum Henrik H Honoré Bent B

Experimental eye research 20190711

Few data exist regarding the protein composition of idiopathic epiretinal membrane (iERM). In the present study we compared the proteome of epiretinal membrane of iERM with the proteome of the inner limiting membrane (ILM) of idiopathic macular hole (iMH). Twelve epiretinal membrane samples were obtained from patients with iERM undergoing therapeutic vitrectomy. Twelve ILM samples from patients with iMH were used as controls. Proteomic analysis was conducted with discovery-based label-free quant ...[more]

PMID: 31302158

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