Dataset Information
Sperm-specific proteins and cancer testis antigens exist outside the blood-testis barrier
Ontology highlight
ABSTRACT:
INSTRUMENT(S): impact II
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): Testis, Interstitial Fluid
SUBMITTER: 
Laura Dagley
LAB HEAD: Peter Stanton
PROVIDER: PXD014333 | Pride | 2021-04-01
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| P3129_DTX_1_10_1_1_01_4142.d.zip | Other | |||
| P3129_DTX_1_11_1_1_01_4143.d.zip | Other | |||
| P3129_DTX_1_1_1_1_01_4133.d.zip | Other | |||
| P3129_DTX_1_2_1_1_01_4134.d.zip | Other | |||
| P3129_DTX_1_3_1_1_01_4135.d.zip | Other |
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Publications
Sperm proteins and cancer-testis antigens are released by the seminiferous tubules in mice and men.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20210301 3
Sperm develop from puberty in the seminiferous tubules, inside the blood-testis barrier to prevent their recognition as "non-self" by the immune system, and it is widely assumed that human sperm-specific proteins cannot access the circulatory or immune systems. Sperm-specific proteins aberrantly expressed in cancer, known as cancer-testis antigens (CTAs), are often pursued as cancer biomarkers and therapeutic targets based on the assumption they are neoantigens absent from the circulation in hea ...[more]
