Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Blood Plasma, Liver
SUBMITTER: Daniel Veyel
LAB HEAD: Wolfgang Rist
PROVIDER: PXD014751 | Pride | 2020-01-28
REPOSITORIES: pride
Action | DRS | |||
---|---|---|---|---|
20171221_NASH_01_fraktion.msf | Msf | |||
20171221_NASH_01_fraktion_1.zip | Other | |||
20171221_NASH_01_fraktion_2.zip | Other | |||
20171221_NASH_01_fraktion_3.zip | Other | |||
20171221_NASH_01_fraktion_4.zip | Other |
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Veyel Daniel D Wenger Kathrin K Broermann Andre A Bretschneider Tom T Luippold Andreas H AH Krawczyk Bartlomiej B Rist Wolfgang W Simon Eric E
Scientific reports 20200128 1
Nonalcoholic steatohepatitis (NASH) is a major cause of liver fibrosis with increasing prevalence worldwide. Currently there are no approved drugs available. The development of new therapies is difficult as diagnosis and staging requires biopsies. Consequently, predictive plasma biomarkers would be useful for drug development. Here we present a multi-omics approach to characterize the molecular pathophysiology and to identify new plasma biomarkers in a choline-deficient L-amino acid-defined diet ...[more]