Dataset Information

Probing the Molecular Phenotype of the Transgenerational Ischemia-Resilient Retina

ABSTRACT: A comparative analysis of the proteome of mouse retina with and without ischemic injury and hypoxia conditioning was achieved through discovery-based quantitative proteomics. Retina from each mouse were harvested immediately for Quantitative Discovery-Based Proteomic Workflow. A 10plex TMT experiment was performed comparing each condition of retina proteomes.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Retina

SUBMITTER: Jessie Guidry

LAB HEAD: Jessie J Guidry

PROVIDER: PXD014769 | Pride | 2021-09-08

REPOSITORIES: Pride

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Publications

Intermittent Hypoxia Promotes Functional Neuroprotection from Retinal Ischemia in Untreated First-Generation Offspring: Proteomic Mechanistic Insights.

Harman Jarrod C JC Guidry Jessie J JJ Gidday Jeffrey M JM

Investigative ophthalmology & visual science 20200901 11

<h4>Purpose</h4>Stress can lead to short- or long-term changes in phenotype. Accumulating evidence also supports the transmission of maladaptive phenotypes, induced by adverse stressors, through the germline to manifest in subsequent generations, providing a novel mechanistic basis for the heritability of disease. In the present study in mice, we tested the hypothesis that repeated presentations of a nonharmful conditioning stress, demonstrated previously to protect against retinal ischemia, wil ...[more]

PMID: 32910134

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