Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Carlos Henrique Vieira e Vieira
LAB HEAD: Matthias Selbach
PROVIDER: PXD014841 | Pride | 2021-01-04
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 46 |
Kraushar Matthew L ML Krupp Ferdinand F Harnett Dermot D Turko Paul P Ambrozkiewicz Mateusz C MC Sprink Thiemo T Imami Koshi K Günnigmann Manuel M Zinnall Ulrike U Vieira-Vieira Carlos H CH Schaub Theres T Münster-Wandowski Agnieszka A Bürger Jörg J Borisova Ekaterina E Yamamoto Hiroshi H Rasin Mladen-Roko MR Ohler Uwe U Beule Dieter D Mielke Thorsten T Tarabykin Victor V Landthaler Markus M Kramer Günter G Vida Imre I Selbach Matthias M Spahn Christian M T CMT
Molecular cell 20201222 2
Protein synthesis must be finely tuned in the developing nervous system as the final essential step of gene expression. This study investigates the architecture of ribosomes from the neocortex during neurogenesis, revealing Ebp1 as a high-occupancy 60S peptide tunnel exit (TE) factor during protein synthesis at near-atomic resolution by cryoelectron microscopy (cryo-EM). Ribosome profiling demonstrated Ebp1-60S binding is highest during start codon initiation and N-terminal peptide elongation, r ...[more]