Proteomics

Dataset Information

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Vaginal secretory proteome dynamically changes across the early and mid-trimesters of pregnancy

ABSTRACT: This study investigates the dynamic alterations in high vaginal fluid (HVF) proteome and its correlation with physiological changes during progression of term pregnancy. The HVF samples were collected at three time points as defined as V1 (6-12 weeks), V2 (18-20 weeks) and V3 (26-28 weeks) and SWATH-MS strategy were applied to profile changes in protein expression at early and middle stage of pregnancy. Using in-house generated HVF-specific protein library, 61 proteins (>1.5 fold at V2/V1 or V3/V1, q-value <0.05) changed as a function of gestational age. The stage-specific expression pattern of these proteins was mainly associated with the biology of cervical remolding, fetal development and microbial defense.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cervicovaginal Fluid

SUBMITTER: Bhoj Kumar  

LAB HEAD: Tushar Kanti Maiti

PROVIDER: PXD014846 | Pride | 2021-01-29

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
HUM_REV_CAN_20KiRT.fasta Fasta
HVSOPT.kit Other
HVSOPT.xls Xls
HVS_DDA-PUL481_comlib.kit Other
HVS_DDA-PUL481_comlib.xls Xls
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Publications

Pregnancy is characterized by intense physiological and structural alterations in the vagina, cervix, and overlying fetal membranes. High vaginal fluid (HVF) is a proximal fluid that covers the lower part of the female reproductive system and the severity of vaginal pathology often adversely affects pregnancy outcomes. To identify the correlation of vaginal fluid proteome dynamics and physiological changes during the progression of pregnancy, a longitudinal study was performed on 20 pregnant wom  ...[more]

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