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Metaproteomic study about diet-induced effects on the gut microbiota of patients affected by Crohn's disease

ABSTRACT: Metaproteomic study on fecal samples collected from Crohn's Disease (CD) patients and some Household Healthy Controls (HHC) during an eight week Lof Fat/High fiber diet intervention. Stoo sampling was performed at baseline (V1), week 8 (V2) and week 36 (V3). Protein Identification and quantitation was performed by MetaLab 2.3 (MaxQuant).

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Bacteria Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Stefano Levi Mortera

PROVIDER: MSV000093975 | MassIVE | Thu Feb 01 02:48:00 GMT 2024

SECONDARY ACCESSION(S): PXD049076

REPOSITORIES: MassIVE

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Publications

Metaproteomics reveals diet-induced changes in gut microbiome function according to Crohn's disease location.

Levi Mortera Stefano S Marzano Valeria V Rapisarda Federica F Marangelo Chiara C Pirona Ilaria I Vernocchi Pamela P Di Michele Marta M Del Chierico Federica F Quintero Maria A MA Fernandez Irina I Hazime Hajar H Killian Rose M RM Solis Norma N Ortega Mailenys M Damas Oriana M OM Proksell Siobhan S Kerman David H DH Deshpande Amar R AR Garces Luis L Scaldaferri Franco F Gasbarrini Antonio A Abreu Maria T MT Putignani Lorenza L

Microbiome 20241023 1

<h4>Background</h4>Crohn's disease (CD) is characterized by chronic intestinal inflammation. Diet is a key modifiable factor influencing the gut microbiome (GM) and a risk factor for CD. However, the impact of diet modulation on GM function in CD patients is understudied. Herein, we evaluated the effect of a high-fiber, low-fat diet (the Mi-IBD diet) on GM function in CD patients. All participants were instructed to follow the Mi-IBD diet for 8 weeks. One group of CD patients received one-time d ...[more]

PMID: 39443987

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