Dataset Information

Proteomic of XFZYD Treat Rat Traumatic brain injury with Tandem Mass Tags,We applied TMTs to detect DEPs,and finally screened 105 overlapping DEPs,among them, there were 17 reversal proteins.According to the bio-function analysis

ABSTRACT: We applied TMTs to detect and study DEPs in the brain cortex of rats in the acute phase of the TBI and revealed the possible mechanism of XFZYD in the treatment of TBI based on bioinformatics analysis.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

DISEASE(S): Wounds And Injuries

SUBMITTER: Dan Zhou

LAB HEAD: Dan Zhou

PROVIDER: PXD014923 | Pride | 2020-04-17

REPOSITORIES: pride

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Publications

TMT-based proteomics analysis reveals the protective effects of Xuefu Zhuyu decoction in a rat model of traumatic brain injury.

Zhou Dan D Liu Jiamiao J Hang Yang Y Li Teng T Li Pengfei P Guo Shichao S Liu Tao T Xia Zian Z Wang Yang Y

Journal of ethnopharmacology 20200413

<h4>Ethnopharmacological relevance</h4>Xuefu Zhuyu decoction (XFZYD) is a traditional Chinese herbal prescription. It is effective in treating traumatic brain injury (TBI). However, the underlying molecular mechanisms remain unclear.<h4>Aim of the study</h4>This study aimed to reveal the possible mechanisms of XFZYD in treating acute TBI through proteomics clues.<h4>Materials and methods</h4>Controlled Cortical Impact (CCI) rats were given gavage administration of XFZYD (9 g/kg/d) or distilled w ...[more]

PMID: 32298754

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