Proteomics

Dataset Information

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Identification of novel binding proteins for sphingosine 1-phosphate


ABSTRACT: Novel binding proteins for bioactive lipid mediator sphingosine 1-phosphate (S1P) were searched in the plasma from apolipoprotein M/albumin double deficient mice.

INSTRUMENT(S): Hitachi instrument model

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Plasma

SUBMITTER: Touko Hirano  

LAB HEAD: Hideru Obinata

PROVIDER: PXD015023 | Pride | 2019-09-04

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
01_F004601.mzid.gz Mzid
01_F004601.pride.mztab.gz Mztab
02_F004602.mzid.gz Mzid
02_F004602.pride.mztab.gz Mztab
03_F004603.mzid.gz Mzid
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Publications

Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice.

Obinata Hideru H   Kuo Andrew A   Wada Yukata Y   Swendeman Steven S   Liu Catherine H CH   Blaho Victoria A VA   Nagumo Rieko R   Satoh Kenichi K   Izumi Takashi T   Hla Timothy T  

Journal of lipid research 20190828 11


HDL-bound ApoM and albumin are protein chaperones for the circulating bioactive lipid, sphingosine 1-phosphate (S1P); in this role, they support essential extracellular S1P signaling functions in the vascular and immune systems. We previously showed that ApoM- and albumin-bound S1P exhibit differences in receptor activation and biological functions. Whether the physiological functions of S1P require chaperones is not clear. We examined ApoM-deficient, albumin-deficient, and double-KO (DKO) mice  ...[more]

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