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The kinetoplastid outer kinetochore

ABSTRACT: In spite of their universal function, the composition of kinetochores differs greatly across eukaryotes. Trypanosomes and other organisms Kinetoplastida diverged very early during eukaryotic radiation from the line that includes animals and fungi, and build kinetochores with very little detectable homology to models. However, the full extent of the trypanosome kinetochore is unclear. Here, we have used quantitative proteomics from multiple start points to define the interaction network of the kinetoplastid kinetochore-interacting proteins (KKIPs). These data identify new components of the kinetochore and define a stable 9-protein complex distal to KKIP1 that forms the majority of the kinetoplastid outer kinetochore.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Trypanosoma Brucei

SUBMITTER: Bill Wickstead

LAB HEAD: Bill Wickstead

PROVIDER: PXD015100 | Pride | 2020-04-27

REPOSITORIES: Pride

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			Action	DRS
	KKIP1-lo_xlinking-IP.mgf	Mgf
	KKIP1-lo_xlinking-IP.raw	Raw
	KKIP1-no_xlinking-IP.mgf	Mgf
	KKIP1-no_xlinking-IP.raw	Raw
	KKIP10-IP.mgf	Mgf

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