Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain, Neutrophil
SUBMITTER: Sheng Zhang
LAB HEAD: Sheng Zhang
PROVIDER: PXD015124 | Pride | 2021-12-08
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
Gary351773_TMT10plex_10fracCombined.mgf | Mgf | |||
Gary351773_TMT10plex_10fracCombined.msf | Msf | |||
Gary351773_TMT10plex_F1.raw | Raw | |||
Gary351773_TMT10plex_F10.raw | Raw | |||
Gary351773_TMT10plex_F2.raw | Raw |
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Journal of neurochemistry 20210512 2
Metabolic changes that correlate to cognitive changes are well-known in Alzheimer's disease (AD). Metabolism is often linked to functional changes in proteins by post-translational modifications. The importance of the regulation of transcription by acetylation is well documented. Advanced mass spectrometry reveals hundreds of acetylated proteins in multiple tissues, but the acetylome of human brain, its functional significance, and the changes with disease are unknown. Filling this gap is critic ...[more]