Proteomics

Dataset Information

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Quantitative Proteomic Profiling for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasm using Pancreatic Cyst Fluid


ABSTRACT: The increased number of pancreatic cyst lesions (PCLs) have been detected through the development of abdominal imaging techniques, such as computed tomography (CT), magnetic resonance imaging (MRI), and endoscopic ultrasound (EUS). However, accurate classification of cystic lesions is difficult because of the lack of standardized diagnostic methods, and thus potentially unnecessary surgical resection has been performed on pancreatic cyst patients. Among four most common types of cystic lesions of pancreas, intraductal papillary mucinous neoplasms (IPMNs), mucinous cystic neoplasms (MCN), serous cystic neoplasms (SCN), and solid pseudopapillary neoplasms (SPNs), IPMNs, the precursor lesion of pancreatic cancer, have been detected most frequently, and are subdivided into low-grade dysplasia (LGD), high-grade dysplasia (HGD), and invasive IPMN in accordance with their malignancy. To discover the potential biomarkers of the histological grades of IPMN, we investigated pancreatic cyst fluid proteins that are differentially expressed in accordance with the IPMN malignancy by LC-MS/MS analysis.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cyst

DISEASE(S): Pancreatic Intraductal Papillary-mucinous Neoplasm

SUBMITTER: Misol Do  

LAB HEAD: Youngsoo Kim

PROVIDER: PXD016127 | Pride | 2020-09-06

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Indv_PC_fluid_HGD1_TR1.raw Raw
Indv_PC_fluid_HGD1_TR2.raw Raw
Indv_PC_fluid_HGD1_TR3.raw Raw
Indv_PC_fluid_HGD2_TR1.raw Raw
Indv_PC_fluid_HGD2_TR2.raw Raw
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Publications

Marker Identification of the Grade of Dysplasia of Intraductal Papillary Mucinous Neoplasm in Pancreatic Cyst Fluid by Quantitative Proteomic Profiling.

Do Misol M   Kim Hongbeom H   Shin Dongyoon D   Park Joonho J   Kim Haeryoung H   Han Youngmin Y   Jang Jin-Young JY   Kim Youngsoo Y  

Cancers 20200823 9


The incidence of patients with pancreatic cystic lesions, particularly intraductal papillary mucinous neoplasm (IPMN), is increasing. Current guidelines, which primarily consider radiological features and laboratory data, have had limited success in predicting malignant IPMN. The lack of a definitive diagnostic method has led to low-risk IPMN patients undergoing unnecessary surgeries. To address this issue, we discovered IPMN marker candidates by analyzing pancreatic cystic fluid by mass spectro  ...[more]

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