Proteomics

Dataset Information

0

Rabbit Liver LC-MS/MS for characterization of two important proteins.


ABSTRACT: This study purified two enzymes from rabbit liver capable of catalyzing the NADPH-dependent conversion of erythrose to erythritol: alcohol dehydrogenase 1 (ADH1) and sorbitol dehydrogenase (SORD).

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Liver

SUBMITTER: Sheng Zhang  

LAB HEAD: Sheng Zhang

PROVIDER: PXD015178 | Pride | 2019-09-09

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
MarthaField10376421_A1.mgf Mgf
MarthaField10376421_A1.msf Msf
MarthaField10376421_A1.raw Raw
MarthaField10376421_B1.mgf Mgf
MarthaField10376421_B1.msf Msf
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Publications

Unexpected roles for ADH1 and SORD in catalyzing the final step of erythritol biosynthesis.

Schlicker Lisa L   Szebenyi Doletha M E DME   Ortiz Semira R SR   Heinz Alexander A   Hiller Karsten K   Field Martha S MS  

The Journal of biological chemistry 20190911 44


The low-calorie sweetener erythritol is endogenously produced from glucose through the pentose phosphate pathway in humans. Erythritol is of medical interest because elevated plasma levels of this polyol are predictive for visceral adiposity gain and development of type 2 diabetes. However, the mechanisms behind these associations remain unknown because the erythritol biosynthesis pathway, particularly the enzyme catalyzing the final step of erythritol synthesis (reduction of erythrose to erythr  ...[more]

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