Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Staphylococcus Aureus
SUBMITTER: Stephan M. Hacker
LAB HEAD: Dr. Stephan M. Hacker
PROVIDER: PXD015457 | Pride | 2019-12-02
REPOSITORIES: Pride
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Zanon Patrick R A PRA Lewald Lisa L Hacker Stephan M SM
Angewandte Chemie (International ed. in English) 20200107 7
Rapid development of bacterial resistance has led to an urgent need to find new druggable targets for antibiotics. In this context, residue-specific chemoproteomic approaches enable proteome-wide identification of binding sites for covalent inhibitors. Described here are easily synthesized isotopically labeled desthiobiotin azide (isoDTB) tags that shortened the chemoproteomic workflow and allowed an increased coverage of cysteines in bacterial systems. They were used to quantify 59 % of all cys ...[more]