Dataset Information

Calretinin is a novel candidate marker for adverse ovarian effects of early life exposure to mixtures of endocrine disruptors in the rat

ABSTRACT: The effect of prenatal and lactational exposure to 4 mixtures of endocrine-didsrupting compounds (Antiandrogen mix, AA; Estrogenic mix, E; Paracetamol, P, and Totalmix, TM) on the early postnatal ovary.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Ovary

SUBMITTER: Panagiotis Filis

LAB HEAD: Panagiotis Filis

PROVIDER: PXD015470 | Pride | 2020-04-01

REPOSITORIES: Pride

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Calretinin is a novel candidate marker for adverse ovarian effects of early life exposure to mixtures of endocrine disruptors in the rat.

Johansson Hanna Katarina Lilith HKL Svingen Terje T Boberg Julie J Fowler Paul A PA Stead David D Vinggaard Anne Marie AM Filis Panagiotis P

Archives of toxicology 20200327 4

Disruption of sensitive stages of ovary development during fetal and perinatal life can have severe and life-long consequences for a woman's reproductive life. Exposure to endocrine disrupting chemicals may affect ovarian development, leading to subsequent reproductive disorders. Here, we investigated the effect of early life exposure to defined mixtures of human-relevant endocrine disrupting chemicals on the rat ovary. We aimed to identify molecular events involved in pathogenesis of ovarian dy ...[more]

PMID: 32221642

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