Dataset Information

The effects of fetal prenatal androgen and estrogenic exposure on the health of adult animals

ABSTRACT: Prenatal exposure to androgens and estrogens and their effect on liver development

INSTRUMENT(S): Q Exactive

ORGANISM(S): Ovis Aries

TISSUE(S): Liver

SUBMITTER: Panagiotis Filis

LAB HEAD: Mick Rae

PROVIDER: PXD014050 | Pride | 2020-01-09

REPOSITORIES: Pride

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Fetal androgen exposure is a determinant of adult male metabolic health.

Siemienowicz Katarzyna J KJ Filis Panagiotis P Shaw Sophie S Douglas Alex A Thomas Jennifer J Mulroy Sally S Howie Forbes F Fowler Paul A PA Duncan W Colin WC Rae Mick T MT

Scientific reports 20191227 1

Androgen signalling is a critical driver of male development. Fetal steroid signalling can be dysregulated by a range of environmental insults and clinical conditions. We hypothesised that poor adult male health was partially attributable to aberrant androgen exposure during development. Testosterone was directly administered to developing male ovine fetuses to model excess prenatal androgenic overexposure associated with conditions such as polycystic ovary syndrome (PCOS). Such in utero androge ...[more]

PMID: 31882954

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Dataset Information

The effects of fetal prenatal androgen and estrogenic exposure on the health of adult animals

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Publications

Fetal androgen exposure is a determinant of adult male metabolic health.

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