Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Bogdan Florea
LAB HEAD: Mario van der Stelt, PhD
PROVIDER: PXD015495 | Pride | 2019-12-18
REPOSITORIES: Pride
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Koenders Sebastiaan T A STA Wijaya Lukas S LS Erkelens Martje N MN Bakker Alexander T AT van der Noord Vera E VE van Rooden Eva J EJ Burggraaff Lindsey L Putter Pasquale C PC Botter Else E Wals Kim K van den Elst Hans H den Dulk Hans H Florea Bogdan I BI van de Water Bob B van Westen Gerard J P GJP Mebius Reina E RE Overkleeft Herman S HS Le Dévédec Sylvia E SE van der Stelt Mario M
ACS central science 20191212 12
Retinaldehyde dehydrogenases belong to a superfamily of enzymes that regulate cell differentiation and are responsible for detoxification of anticancer drugs. Chemical tools and methods are of great utility to visualize and quantify aldehyde dehydrogenase (ALDH) activity in health and disease. Here, we present the discovery of a first-in-class chemical probe based on retinal, the endogenous substrate of retinal ALDHs. We unveil the utility of this probe in quantitating ALDH isozyme activity in a ...[more]