Proteomics

Dataset Information

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Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans

ABSTRACT: The CFP1 CXXC zinc finger protein targets the SET1/COMPASS complex to nonmethylated CpG rich promoters to implement tri-methylation of histone H3 Lys4 (H3K4me3). Although H3K4me3 is widely associated with gene expression, the effects of CFP1 loss vary, suggesting additional chromatin factors contribute to context dependent effects. Using a proteomics approach, we identified CFP1 associated proteins and an unexpected direct link between C. elegans CFP-1 and an Rpd3/Sin3 small (SIN3S) histone deacetylase complex.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Caenorhabditis Elegans

SUBMITTER: Yohann Couté  

LAB HEAD: Virginie Brun

PROVIDER: PXD015548 | Pride | 2019-09-27

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Cfp-1.mgf Mgf
Cfp-1.mzid.gz Mzid
Cfp-1.pride.mgf.gz Mgf
Cfp-1.pride.mztab.gz Mztab
Cfp-1.raw Raw
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Publications

Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans.

Beurton Flore F   Stempor Przemyslaw P   Caron Matthieu M   Appert Alex A   Dong Yan Y   Chen Ron A-J RA   Cluet David D   Couté Yohann Y   Herbette Marion M   Huang Ni N   Polveche Hélène H   Spichty Martin M   Bedet Cécile C   Ahringer Julie J   Palladino Francesca F  

Nucleic acids research 20191201 21

The CFP1 CXXC zinc finger protein targets the SET1/COMPASS complex to non-methylated CpG rich promoters to implement tri-methylation of histone H3 Lys4 (H3K4me3). Although H3K4me3 is widely associated with gene expression, the effects of CFP1 loss vary, suggesting additional chromatin factors contribute to context dependent effects. Using a proteomics approach, we identified CFP1 associated proteins and an unexpected direct link between Caenorhabditis elegans CFP-1 and an Rpd3/Sin3 small (SIN3S)  ...[more]